202 - The potential diagnostic role of HbA1c level in septic patients with diabetes (ID 1316)
Abstract
Background and Aims
Type 2 diabetes mellitus is a common risk factor of atherosclerosis. Due to the markable metabolic changes these patients are susceptible to sepsis. The potential role of hemoglobin A1c (HbA1c) in diabetic, septic patients has not yet been studied.
Methods
We enrolled diabetic patients with diagnosis of sepsis based on the Systemic Inflammatory Response Syndrome (SIRS) criteria (112 patients, SIRS group) - who had HbA1c levels measured either in the previous 30 days (SIRS 30d subgroup – 39 patients) or within 24 hours after their admission (SIRS 24h subgroup – 73 patients). We selected those patients from the SIRS group, whose Sequential Organ Failure Assessment (SOFA) score was ≥ 2 (55 patients, SOFA group). They were also divided into 2 subgroups based on weather HbA1c was measured either in the previous 30 days (SOFA 30d subgroup – 21 patients) or within 24 hours after their admission (SOFA 24h subgroup – 34 patients). Sepsis specific laboratory parameters, glucose, HbA1c and length of hospital stay were analyzed.
Results
Significant positive correlation was found between glucose and HbA1c level; indeed significant negative correlations observed between white blood cell count and glucose level, white blood cell count and HbA1c level in the SIRS 24h as well as in the SOFA 24h patients. There was a positive correlation between length of hospital stay and HbA1c in SOFA 24h group.
Conclusions
Measurement of HbA1c within 24 hours upon Emergency Department admission might be an additional prognostic biomarker in septic patients with type 2 diabetes mellitus.
