188 - Modulation of cholesterol efflux capacity (CEC) of high density lipoprotein (HDL) with bariatric surgery (ID 1064)
Abstract
Background and Aims
Clinical and epidemiological studies have demonstrated that obesity has strong causal relationship with numerous comorbidities such as cardiovascular diseases (CVD), type 2 diabetes and hypertension. Bariatric surgery has been shown to alleviate the cardiovascular risk factors. Cholesterol efflux capacity (CEC) of HDL was assessed as a risk factor for CVD in obese subjects before and after surgery
Methods
56 individuals with morbid obesity and 40 lean individuals with BMI less than 25 were recruited. 42 subjects were followed up 3 months after bariatric surgery. Macrophage specific cholesterol efflux capacity of HDL was assessed using THP1 cell line.
Results
Mean age of lean individuals was 42.5 years and for individuals with obesity was 43.3 years. Weight loss observed three months after bariatric surgery was 17.1% (p < 0.0001). Three months after bariatric surgery, there was no change in LDL-C, while a nonsignificant decrease in HDL-C levels was observed. Cholesterol efflux capacity of HDL was significantly lower in individuals with obesity compared to lean individuals (1.04 ± 0.15 vs 0.92 ± 0.16 A.U., p = 0.001). A significant increase in CEC of HDL was found after bariatric surgery independent of the surgical procedure (gastric bypass, n = 25, p = 0.01, sleeve gastrectomy, n = 12, p = 0.03).
Conclusions
Despite the lack of change in HDL-C levels, there was a significant improvement in CEC of HDL, 3 months after bariatric surgery in individuals with morbid obesity and this improvement was independent of the type of surgery.
