Welcome to the 9th EAPS Congress Programme Scheduling
The congress will officially run on Barcelona Time (GMT+2)
To convert the congress times to your local time Click Here
EXPOSURE TO PHENOLIC ENDOCRINE DISRUPTORS AND EARLY THELARCHE
- Paula S. Ventura (Spain)
Abstract
Background and Aims
Early exposure to endocrine disrupting environmental pollutants (EDs) with estrogenic action could influence the age of onset of thelarche and/or puberty in girls.
Objective: to explore differences in the levels of exposure of phenolic EDs with potential estrogenic/anti-androgenic activity (bisphenols/parabens/benzophenones) between girls with early thelarche and healthy girls without this condition.
Methods
Multicenter, case-control study carried out in different geographical areas of Spain. A group of 110 cases and 97 controls was recruited between 2018-2021. In urine samples collected concentrations of three bisphenols (bisphenol A(BPA)/S(BPS)/F(BPF)), four parabens (methyl-(MPB), ethyl-(EPB)/propyl-(PPB)/butyl-paraben(BPP)) and six UV filters from the benzophenone family (BP1/BP3/BP6/BP8/4OHBP). A structured questionnaire was administered to the parents to collect sociodemographic and lifestyle data. In the group of cases, hormonal parameters, bone age and pelvic ultrasound were also determined. Associations were examined by unconditional logistic regression models adjusted for hospital, age, BMI z-score, and urinary creatinine.
Results
The participants had a mean age of 6.7(1.6) years. At least one EDs was detected in 99% of all samples tested. The cases presented higher concentrations of BPA, MPB, PPB, BP1, BP3 and 4OHBP, the difference being statistically significant only in BPA.
Conclusions
Conclusions: Phenolic EDs have been detected in practically all the samples analyzed, indicating that there is widespread exposure to EDs in school-age girls. Urinary concentrations of BPA, a compound with demonstrated estrogenic action, appear to be higher in girls with early thelarche. It is necessary to continue studying the possible influence of exposure to EDs on the risk of precocious thelarche and puberty.