Triple-negative breast cancer (TNBC) is defined by the absence of estrogen receptor (ER), progesterone receptor (PR), and no amplification of the human epidermal growth factors 2 (HER2) receptor. ATP-binding cassette superfamily G member 2 (ABCG2) is a transport protein that functions to eliminate xenobiotics in ATP dependent manner. The genetic variations might alter the gene expression, substrate specificity, and xenobiotics elimination function which ultimately affect the susceptibility of individuals towards cancer. The aim of this study is to investigate the association of
Genomic DNA was extracted from blood samples of 75 TNBC patients and 100 normal controls. The genotyping was performed by using the PCR-RFLP method and the genotype pattern was grouped into three, which are homozygous wildtype, heterozygous and homozygous variant. The genotype, allele, and haplotype frequencies with TNBC and pathological variables were calculated by using the independent χ2 test whereas the level of association was evaluated by deriving odds ratio (OR) with 95% confidence intervals (CI) using binary logistic regression analysis.
The
In conclusion,
Ahmad Aizat Abdul Aziz.
This study was supported by Universiti Sains Malaysia Short Term Grant (304/PPSP/6315508).
All authors have declared no conflicts of interest.