Gene expression profiling (GEP)-based prognostic signatures are rapidly integrated into clinical decision-making for systemic management of breast cancer patients. However, GEP remains relatively underdeveloped for loco-regional risk assessment. Yet, local-regional recurrence (LRR), especially early after surgery, is associated with poor survival.
GEP was performed on two independent luminal-like breast cancer cohorts of patients developing early (≤ 5 years after surgery) or late (>5 years) LRR and used, by training and testing approach, to build a gene signature able to intercept women at risk of developing early LRR. The GEP data of two
Analysis of the first two cohorts lead to the identification of three genes,
Our 3-gene signature represents a new exploitable tool to aid treatment choice in patients with luminal-like breast cancer at risk of developing early recurrence.
AIRC (Italian Association for Cancer Research), Grants to MPC (AIRC IG #18425 and AIRC IG #24363) and Italian Ministry of Health, “Ricerca corrente” Funds.
All authors have declared no conflicts of interest.