Poster lunch (ID 46) Poster display session

164P - Locoregional therapy targeted at the primary tumour improves overall survival in patients with stage IV metastatic breast cancer: A systematic review and meta-analysis with 185942 patients (ID 709)

Presentation Number
164P
Lecture Time
12:15 - 12:15
Speakers
  • Ritika Gera (London, United Kingdom)
Session Name
Poster lunch (ID 46)
Location
Exhibition area, MARITIM Hotel Berlin, Berlin, Germany
Date
03.05.2019
Time
12:15 - 13:00

Abstract

Background

Metastatic breast cancer is a complex disease that is traditionally treated using systemic therapy. There is mounting evidence that locoregional therapy (LRT), such as resection of the primary tumour and/or localised radiotherapy could be associated with improvements in survival. We aimed to conduct a meta-analysis to inform decision making.

Methods

Using the PubMed, Cochrane and Ovid SP databases, a literature review and meta-analysis was undertaken in order to assess whether LRT of the primary tumour in metastatic breast cancer prolongs survival.

Results

43 studies were analysed for the impact of LRT on survival which shown a significant 33.3% reduction in mortality with LRT (HR = 0.667:95% CI 0.617-0.721) and 37.3% with resection alone (N = 41; HR = 0.623: 95% CI 0.586-0.661).

Conclusions

This is the largest meta-analysis regarding this question to date. LRT seems to improve overall survival in de novo disease and should be considered in selected patients after a multidisciplinary discussion.

Legal entity responsible for the study

London Breast Institute.

Funding

Has not received any funding.

Disclosure

All authors have declared no conflicts of interest.

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