Poster lunch (ID 46) Poster display session

131P - A prospective comparative study of sentinel lymph node biopsy with indo-cyanine green (ICG) florescence technique versus dual dye technique for early breast cancer: Going beyond the horizon (ID 563)

Presentation Number
131P
Lecture Time
12:15 - 12:15
Speakers
  • Ashwin KR (Bangalore, Karnataka, India)
Session Name
Poster lunch (ID 46)
Location
Exhibition area, MARITIM Hotel Berlin, Berlin, Germany
Date
03.05.2019
Time
12:15 - 13:00

Abstract

Background

The dual technique with radio colloid and blue dye is the gold standard in sentinel lymph node biopsy (SLNB) to stage axilla in breast cancer. The objective of the present study was to assess the diagnostic performance of sentinel lymph node (SLN) biopsy using the indocyanine green (ICG) fluorescence method compared with that using the conventional method in detection of sentinel lymph nodes.

Methods

60 patients diagnosed with early breast cancer underwent the SLNB procedure using technetium‐99m radio colloid (R), methylene blue dye (MB), and ICG. All SLNs that were removed during surgery were labelled as hot, blue or/and fluorescent and sent for pathological examination. The detection rate of SLNs and positive SLNs, and the number of SLNs of ICG, MB+ R, ICG + MB, ICG + R were compared. Injection safety of ICG and MB was evaluated.

Results

Sentinel Lymph Node was identified in all 60 cases. Total Sentinel lymph nodes removed was 145 (Mean=2, Range 2-5), ICG was able to identify more nodes than the dual dye technique. The identification rate with the dual dye technique was 95%, with blue dye alone 93.6% and with radioisotope alone 96.8% whereas with ICG alone was 100%, with ICG + MB was 96.6% & ICG + R was 96.6 %. 28(46.6%) out of 60 patients had positive nodes which was identified by both dual dye & ICG. None of the patients had any local or systemic reaction with ICG, 3 patients with blue dye had tattooing & staining of skin.

Conclusions

ICG is as effective as the dual dye for SLNB. In addition, as a near-infrared dye, it has the advantages of real-time visualization, lower cost, and wider availability, since no radioactive material needs to be handled. It can be a boon for developed countries & second tier centers of developing country where there is limited access to nuclear medicine department facility & the cost involved in its establishment. A combination of blue dye and ICG is useful dual approach when radioisotope is unavailable.

Legal entity responsible for the study

Manipal Hospital.

Funding

Has not received any funding.

Disclosure

All authors have declared no conflicts of interest.

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