Presenter of 1 Presentation
O046 - AUTOIMMUNE HEMOLYTIC ANEMIA AFTER COVID-19 VACCINATION: A ONE YEAR CASE REVISION IN A CLINICAL AUTOIMMUNE LABORATORY (ID 405)
Abstract
Background and Aims
Coronavirus 2019 disease (COVID‐19) is still ongoing two years after the beginning of this pandemic. COVID 19 early vaccination development was one of the most challenging scientific breakthroughs of all mankind. Although major disease complications are now coming to our clinical settings, early post vaccination autoimmune manifestations have caught our eye mainly concerning hematological diseases like autoimmune hemolytic anemia and immune thrombocytopenic purpura. Other autoimmune diseases like thyroiditis, Kawasaki disease, Guillain‐Barre syndrome, as well as other autoantibody detection has revealed the potential of COVID‐19 in inducing autoimmune response.
Methods
We revised 4 cases of autoimmune hemolytic anemia in older patients following early vaccination period with mRNA vaccine, focusing in vaccination time frame, hemolytic markers and clinical manifestations.
Results
All of our patients had preexisting conditions, and although disease was time limited, it was not mild, as they all required hospitalization for hemodynamic and proinflammatory response control.
Conclusions
Autoimmune hematological disorders after COVID-19 vaccines should come into our mind as some patients may have higher risk of thrombotic complications. Monitoring of blood counts and early hemolytic markers as well as patient education are key for early diagnosis and management.