006 - EFFECT OF INTERFERON-BETA TREATMENT ON THE PROPORTION OF REGULATORY T CELLS IN MULTIPLE SCLEROSIS: A META-ANALYSIS (ID 96)
Abstract
Background and Aims
The balance between Th17 cells and Tregs is impaired in MS. Increasing the number of Tregs can both prevent and reverse disease. However, the influence of IFN-β on the proportion of Tregs in MS remains controversial. We did a meta-analysis of the results published previously to assess the role of IFN-β on Tregs in MS patients.
Methods
We searched PubMed, Cochrane, EMBASE, Web of science for studies reporting the influence of IFN-β on the proportion of Tregs in MS patients. Our main endpoint was the proportion of Tregs in PB. We assessed pooled data by using the REM. It has been registered at PROSPERO (CRD42017065283).
Results
Of 314 identified studies, a total of 12 studies were selected in our analysis. There was no significant difference between MS patients with IFN-β treatment and control subjects in Tregs identified by all Tregs definition methods [0.31, (−0.03, 0.65), P=0.071] and Tregs defined by “CD4+ CD25+” [0.17, (−0.20, 0.54), P =0.379]. Compared with control subjects, MS patients with IFN-β treatment had a higher proportion of Tregs defined by “CD4+ CD25+ FOXP3+” [0.79, (0.28, 1.29), P =0.002].
Conclusions
The data showed that the results of Tregs were different according to the definition methods; and the proportion of Tregs defined by “CD4+ CD25+ FOXP3+” was increased in MS patients with IFN-β treatment compared with control subjects. The results demonstrated that IFN-β can reduce the severity of MS patients by regulating Tregs.
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