Krasimir I. Kraev, Bulgaria

UMHAT Kaspela Rheumatology
I have graduated medicine in 2014 and as soon as end of that year I have become assistant professor in Internal diseases in Medical University-Plovdiv, Bulgaria. I have been specialist in Rheumatology since may 2019 and have completed my PhD in september 2020, the topic was Anti-drug antibodies produced against TNF-alpha blockers in patients with inflammatory joint diseases! My personal interest consist of the development of personal medicine in Rheumatology, cytokine profiles and of course vasculitides!

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RELATIONSHIP BETWEEN TNF-Α AND IL-6 LEVELS AND ACTIVITY INDICES IN PATIENTS WITH INFLAMMATORY JOINT DISEASES

Session Name
PS04 - IL17, TH17 AND OTHER CYTOKINES IN AUTOIMMUNITY
Session Type
PARALLEL SESSIONS
Date
29.05.2021, Saturday
Session Time
10:00 - 12:00
Room
HALL D
Lecture Time
11:30 - 11:40
Presenter
Session Icon
Pre Recorded

Abstract

Background and Aims

Unlimited cytokine production regulates chronic inflammation and joint destruction in patients with inflammatory joint diseases. Chronic inflammation in such patients is induced by the imbalance between the pro- and antiinflammatory cytokines.Potential triggers for this process are the pro-inflammatory cytokines TNF-α and IL-6. The aim of the study is to assess the correlation between their levels and the activity indices in patients with inflammatory joint diseases .

Methods

213 patients with RA, AS and PsA and a control group of 31 healthy subjects were studied.All patients were tested for TNF-α and IL-6 prior to treatment initiation with blockers of TNF-α.Disease indices were used to evaluate disease activity.

Results

There is strong correlation between serum levels of TNF-α and IL-6 prior treatment in patients with RA(rs=-0.018;p=0.001). Similar relationship exists between the tested cytokines and the index of activity and HAQ-DI (rs=0.033;p=0.003). (Rs=-0.025;p=0.001)Between the levels of TNF-α and IL-6 prior treatment initiation in patients with AS has a strong correlation(rs=-0.010;p=0.004). Relationship exists between the cytokines and activity index BASFI, ASDAS and BASDAI, respectively for TNF-α (rs=-0.176;p=0.041),(rs=0.342;p=0.001),(rs=367;p=0.001) and for IL-6(rs=0.406,p=0.016),(rs=-0.083;p=0.002),(rs=263;p=0.001). Between levels of TNF-α and IL-6 prior treatment in patients with PsA no significant correlation was observed(rs=-0.031;p =0.827).There was also no significant correlation between DAPSA index and IL-6 (rs=-0.187;p=0.237) and between IL-6 and HAQ-DI (rs=-0.035;p =0.827) .

Conclusions

Between the serum levels of TNF -α and IL -6, and the indices for activity in patients with inflammatory joint disease there is a strong correlation relationship, which reflects the importance of these cytokines for clinical evaluation of patients.

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