Giovanni Annuzzi, Italy
Federico II University Clinical Medicine and SurgeryAuthor Of 1 Presentation
OP036 - MANAGEMENT OF PROLONGED AEROBIC EXERCISE IN PATIENTS WITH TYPE 1 DIABETES ON ADVANCED TECHNOLOGIES (MARTA) (ID 905)
Abstract
Background and Aims
Managing physical activity in individuals with type 1 diabetes (T1DM) is very complex due to the
variability of glycemic response to exercise. We aimed to identify an optimal strategy for the
management of prolonged aerobic exercise in sedentary/moderately active T1DM patients using
hybrid artificial pancreas (HAP).
Methods
According to a randomized, cross-over study design, individuals with T1DM on HAP, both genders,
age >18 years, no contraindications to prolonged aerobic physical activity, underwent on different
occasions one-month apart to three walk mountain sessions with similar characteristics (distance,
approximately 10 km; duration, 4 hours; difference in altitude, 200-300 m). Three different
therapeutic/nutritional approaches were compared: 1) exercise glycemic target (Target); 2)
carbohydrate integration, 15 g complex carbohydrates every 30 minutes during the session
(Snack); 3) exercise glycemic target and carbohydrate integration (Target+Snack). Blood glucose
control during the exercise sessions was assessed by CGM.
Results
Preliminary analysis (n=7) shows that the Target intervention determined a significantly higher
time in range (TIR 70-180 mg/dl) (95.3±7.5%) compared to Target+Snack (70.6±19.4%) and Snack
(89.1±10.8%) (p=0.020, two-way repeated measures analysis), and a significantly reduced time
above range (TAR 180-250 mg/dl) (4.4±7.6%) compared to Target+Snack (19±14.5%) and Snack
(9.1±11.3%)(p=0.007).
Conclusions
In patients with T1DM on HAP, the modification of the glycemic target resulted in a better
glycemic control during prolonged aerobic exercise than only supplementing complex
carbohydrates or combining both strategies.