Emma G. Wilmot, United Kingdom
University Hospitals of Derby and Burton NHS FT Diabetes & EndocrinololgyPresenter of 4 Presentations
Insulin in the evolving experience of people living with diabetes
Q&A session
RISK FACTORS FOR DIABETES-RELATED DISTRESS IN PEOPLE LIVING WITH TYPE 1 DIABETES –LESSONS FROM THE ASSOCIATION OF BRITISH CLINICAL DIABETOLOGISTS (ABCD) FREESTYLE LIBRE AUDIT
- Emma G. Wilmot, United Kingdom
- Harshal Deshmukh, United Kingdom
- Robert Gregory, United Kingdom
- Anne Kilvert, United Kingdom
- Dennis Barnes, United Kingdom
- Roselle Herring, United Kingdom
- Rumaisa Banatwalla, United Kingdom
- Parth Narendran, United Kingdom
- Jane Patmore, United Kingdom
- Chris Walton, United Kingdom
- Thozhukat Sathyapalan, United Kingdom
- REJ Ryder, United Kingdom
Abstract
Background and Aims
The objective of this study was to identify the baseline demographic and clinical characteristics associated with Diabetes-related distress in people living with Type 1 diabetes.
Methods
The study was performed using baseline data from the ABCD nationwide FreeStyle Libre audit. We collected diabetes-related distress scores at baseline with two items diabetes-related distress score (DDS) and follow up. An average item score of ≥3 (moderate distress) discriminated high from low-distressed subgroups. We used an unsupervised gradient boosting machine learning model (GBM) to identify the relative influence of baseline parameters on two components of DDS. The results of the GBM model were confirmed using linear regression analysis.
Results
The study consisted of 9124 people with Type 1 diabetes, with a mean age of 45.1(±15.3) years, 50.3% female, mean BMI of 26.5(±6.2) kg/m2 and mean baseline HbA1c 70.2(±18.3) mmol/mol. High diabetes-related distress was prevalent in 5476(60%) of people living with T1D at baseline. The two components of the DDS were significantly correlated (r2=0.73 P<0.0001). In the GBM model, baseline HbA1c (RI=51.4), GOLD score (RI=23.3), gender (RI=7.05) and fear of hypoglycaemia as an indication for starting on the FSL (RI=4.9) were associated with diabetes-related distress. The linear regression model confirmed that higher baseline HbA1c, higher GOLD score, female gender and fear of hypoglycaemia were significantly associated with DDS.
Conclusions
In this large UK cohort of people living with Type 1 diabetes, diabetes distress was prevalent and associated with high HbA1c, impaired awareness of hypoglycaemia and female gender.
The effectiveness of isCGM: comparison of data from RCTs and routine-use
Abstract
Abstract Body
For decades finger prick self-monitoring of blood glucose (SMBG) has been the cornerstone of diabetes self-management, with the expectation that people with diabetes undertake SMBG at multiple points across the day to inform treatment decisions. Intermittently scanned continuous glucose monitoring (isCGM) has more recently become established as an alternative to finger prick SMBG. Individuals wear a sensor on the arm which is scanned with a reader, allowing the user to visualise the glucose information. This contrasts to real time CGM systems which allow direct visualisation of the data without the need to scan. Early randomised controlled trials highlighted the ability of isCGM to reduce hypoglycaemia in people living with Type 1 diabetes and Type 2 diabetes. The uptake of isCGM has since risen exponentially, largely replacing finger prick SMBG for many individuals living with diabetes. The latest generation of isCGM is now available with the additional benefit of optional alarms. A range of randomised controlled trials and real-world studies have been undertaken to explore the potential clinical benefits of the different generations of isCGM on outcomes, including HbA1c, hypoglycaemia and patient related outcome measures. This lecture will aim to review these studies and compare the findings of the randomised controlled trials with those of the published real-world data.