Laya Ekhlaspour, United States of America

Stanford University Pediatrics

Presenter of 1 Presentation

DIETARY FAT AND GLUCOSE EXCURSIONS IN PATIENTS USING A CLOSED LOOP SYSTEM

Session Name
ARTIFICIAL PANCREAS
Session Type
E-POSTER VIEWING (EXHIBITION HOURS)
Date
20.02.2020, Thursday
Session Time
09:30 - 15:30
Channel
E-Poster Area
Lecture Time
09:38 - 09:39

Abstract

Background and Aims

Currently most hybrid closed-loop (HCL) insulin delivery systems base the meal bolus solely on the carbohydrate (CHO) content. We explored the glycemic response to dinners with high fat (>30 grams: HF) compared to non-high fat meals (<=30 grams: non-HF) for 8 hours following dinners during a HCL study. The study design required at least half the meals to be high fat.

Methods

There were twenty participants ages 6-61 years old (45% female) in an outpatient, supervised clinical trial. The CHO, protein and fat content of each meal was recorded by the medical staff, using food labels. We used regression techniques to evaluate whether high fat meals were associated with a delayed peak glucose and the time to peak. Because of repeated measurements within participants, we used a generalized linear mixed model.

Results

There were 25 HF dinners and 12 non-HF dinners. Using linear regression, adjusted for carbohydrate content and insulin dosing, there was no association between peak glucose and time to peak and the fat content. We observed a significant difference HF and non-HF meals in glucose levels at each time point between 75 to 205 minutes.

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Conclusions

In this analysis there was no delay in the time to peak glucose with HF meals, mainly because there was no early peak in glucose with non-HF meals. This may be due to the small non-HF meal sample size, with 7 of the 12 meals having 25-30 grams of fat. Further studies with lower fat meals are required.

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