Alexander Seibold, Germany
Abbott Diabetes Care Medical AffairsPresenter of 1 Presentation
IMPROVING HBA1C CONTROL IN PEOPLE WITH TYPE 1 OR TYPE 2 DIABETES USING FLASH GLUCOSE MONITORING: A RETROSPECTIVE OBSERVATIONAL ANALYSIS IN 2 GERMAN CENTRES
Abstract
Background and Aims
To evaluate change in HbA1c in patients with Type 1 (T1D) or Type 2 diabetes (T2D) following initiation of the FreeStyle Libre® flash continuous glucose monitoring system.
Methods
A retrospective observational study was undertaken on adults with T1D (n=131) or T2D on insulin (n=176), who were started on the FreeStyle Libre system. Chart review included patients with HbA1c recorded prior to initiation and at 3- month intervals thereafter.
Results
Mean HbA1c decreased significantly at 3 months after initiation of the FreeStyle Libre system in T1D (mean change -0.75±0.15% (-8.2±1.6 mmol/mol); p<0.001) and in T2D (mean change -0.52±0.11% (-5.7±1.2 mmol/mol); p<0.001). Reduction was maintained for 12 months. Change in HbA1c from 3 months to 12 months was not significant in either T1D or T2D. Subgroup analysis showed significant improvements in patients with mean baseline HbA1c >7.5 % (>58 mmol/mol). Patients with a baseline HbA1c >7.5 % (> 58 mmol/mol) showed a reduction of -1.36±0.34% (-14.9±3.7 mmol/mol) in T1D and a reduction of -1.16±0.38% (-12.7±4.2 mmol/mol) in T2D at 12 months (p<0.001). Linear regression confirms that baseline HbA1c is negatively correlated with change in HbA1c, both in T1D (p<0.001) and in T2D (p<0.001) (Fig 1).
Conclusions
People with T1D or T2D on insulin show a reduction in HbA1c by 3 months following initiation of the FreeStyle Libre system. Fall in HbA1c at 3 months is negatively correlated with starting HbA1c and is maintained over 12 months. The most significant benefit seen in patients with a starting HbA1c >7.5% (>58 mmol/mol).