Nataliya Volkava, Belarus2nd City Children's Hospital endocrinology
Presenter Of 1 Presentation
ANTHROPOMETRIC, IMMUNOLOGICAL AND METABOLIC PARAMETERS IN CHILDREN WITH TYPE 1 DIABETES AND COEXISTING AUTOIMMUNE DISEASES
Background and Aims
Aims: to assess the effects of associated autoimmune diseases on glycemic control, growth, metabolic parameters in children with type 1 diabetes (T1D) and to select the most predictive genetic, immune and metabolic risk factors of polyglandular autoimmunity in children with T1D.
72 children with combined autoimmune pathology (main group, age 11.98±3.79 years) and 75 patients with isolated T1D (control group, age 11.09±3.31 years) were recruited. Groups were comparable in age (p=0.17) and T1D duration (p=0.26). Anthropometric parameters, insulin doses, biochemical blood parameters, glycosylated hemoglobin (HbA1c), thyroid hormones and thyroid peroxidase antibodies (anti-TPO) levels were assessed.
In the main group 49 children had combinations of T1D with autoimmune thyroiditis (AIT), 17 − celiac disease, 2 – Graves' disease, 4 – AIT and celiac disease. Body mass index and height z-scores in both groups corresponded to the mean age values and didn’t differ significantly (p=0.82 and 0.71 respectively). HbA1c level in children with combined autoimmune pathology was higher than in the control group (8.23±1.91% vs 7.47±1.22%, p=0.006). There was no difference in insulin requirement (p=0.93).
Both groups demonstrated similar values of biochemical blood parameters: lipidogram, serum iron, and ferritin (p>0.05). Higher anti-TPO antibodies were revealed in the main group (327.41±469.91 IU/ml) compared to the control group (40.42±26.33 IU/ml, p=0.0001).
At the present stage of the study we hasn’t found any difference in anthropometric and biochemical parameters in children with coexisting disorders compared with patients with isolated T1D. Children with polyglandular autoimmune pathology showed more poor glycemic control indicators.