Sheyda Sofizadeh, SwedenNU-Hospital Group Department of medicine
Presenter Of 1 Presentation
EVALUATION OF THE PROFILE OF BLOOD GLUCOSE USING CGM IN THE POPULATION WITH NORMAL ORAL GLUCOSE TOLERANCE TEST.
Background and Aims
CGM-data is essential in both clinical practice and diabetes studies for evaluating glucose control. To understand what glucose profiles should be judged as normal and for target values in persons with diabetes, we examined the glucose profile in healthy individuals.
Persons without known diabetes or prediabetes were included after passing a normal oral glucose tolerance test, 2-hour value <8.9 mmol/l, fasting glucose <6.1 mmol/l, HbA1c <42 mmol/mol (6.0%). During days 1-8 they wore masked CGM (DexCom G4). During days 8-14 they had an open CGM-system with an alarm at 4.0 mmol/l to regularly confirm with a HemoCue capillary meter the low glucose-levels.
In total 60 persons were included, mean age was 43 years, 70% women, mean HbA1c 34 mmol/mol (5.3%) and mean BMI 25.7 kg/m2. Mean glucose level days 1-7 was 5.83 mmol/l and mean time with hypoglycaemia <4.0 mmol/l /24h was 51 minutes (mean 3.54%, median 1.92 % [range 0.0-25.5%]) and mean time with <3.0 mmol/l /24h was 7.10 minutes (mean 0.49%, median 0.0% [range 0.0-9.5%]). The mean SD was 1.15 mmol/l, CV 0.20 and MAGE 2.63 mmol/l. Mean time with glucose levels >10 mmol/l /24h was 20.8 minutes (mean 1.44%, median 0.25% [range 0.0-19.7%]).
CGM-profiles in persons without diabetes or prediabetes show around 2% of time with glucose levels <4.0 mmol/l and 0%-0.5% <3.0 mmol/l. An SD and CV close to 1.15 mmol/l and 20% respectively should be viewed as a glucose variability close to that of persons without prediabetes or diabetes.