Alessandro Bisio, United States of America

University of Virginia Psychiatry and Neurobehavioral Science

Presenter Of 1 Presentation

DOES CLOSED-LOOP CONTROL (CLC) IMPROVE SLEEP IN VULNERABLE POPULATIONS WITH TYPE 1 DIABETES (T1D)?

Abstract

Background and Aims

Studies have increasingly identified sleep disturbances in people with T1D. Older adults and young children may be a particularly vulnerable population to sleep disturbances. Anecdotally, it is reported that use of CLC improves sleep quality and quantity, but objective data on this effect are not available. This study assesses sleep outcomes of CLC compared to sensor-augmented pump therapy (SAP).

Methods

Participants with T1D on insulin pump therapy were enrolled in two age groups: older adults (ages 65+) and young children (ages 6-10). Participants completed an initial 4-week study with SAP using their own pump and a study CGM (Dexcom G6) followed by a 4-week phase of CLC (Control-IQ, Tandem Diabetes Care). Sleep was assessed using Actigraphy watches worn the last 10 days of each study phase. The Pittsburgh Sleep Quality Index (PSQI) questionnaire was administered at baseline and following each study phase.

Results

A total of 18 older adults (mean age 69) and 15 children (mean age 9) and their parents were enrolled in this ongoing study. Preliminary data analysis was performed on a subset of 4 older male adults. Sleep duration increased an average of 19 minutes during CLC in 2 subjects and remained virtually unaltered in the others. Sleep efficiency did not change. PSQI score improved in the two participants with worse scores on SAP. Results for each participant are shown below.

chart vrif attd.png

Conclusions

Though preliminary, these results suggest that the use of CLC may have a positive impact on the quality of sleep for some older adults with T1D.

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