AS01 Closed-loop System and Algorithm

462 - TRANSLATING STANDARD CLINICAL PROTOCOL INTO TUNING PROCEDURES FOR HYBRID CLOSED LOOP SYSTEMS: 670G, CONTROL-IQ AND LOOP

Session Type
E-POSTER VIEWING (EXHIBITION HOURS)
Session Name
CLOSED-LOOP SYSTEM AND ALGORITHM

Abstract

Background and Aims

The transition of new hybrid closed loop (HCL) artificial pancreas systems from research into widespread clinical use brings exciting advances to diabetes care. However, tuning protocols for current and in-trial systems vary significantly. This work seeks to establish a comprehensive guide for clinicians for translating clinical practice into tuning procedures for patients on the Medtronic 670G, Tandem Control-IQ, and Do-It Yourself (DIY) Loop systems.

Methods

Retroactive patient data, in-silico HCL implementation, algorithmic analysis and clinical experience is utilized to correlate features in blood glucose profiles with adjustments in HCL parameters leading to improved control. Parameters and tuning protocols for the Medtronic 670G, Control-IQ, and DIY Loop systems are compared against standard clinical guidelines for setting basal rates, insulin sensitivity, correction factors, carb ratio, and additional control set points when applicable.

Results

Tuning procedures for each parameter setting across devices, with detailed descriptions and simplified tables will be presented. Figures demonstrating effects of parameter changes on insulin dosing for each system, along with cases for when to adjust a certain parameter will be shown. In all we find 2 adjustable parameters in 670G, 5 in Control IQ and 10 in Loop. Fig. 1 depicts an example table for one parameter: "Target Range".

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Conclusions

As additional HCL systems enter the clinical market and popularity of DIY systems grows, it is vital for clinicians to understand differences and similarities between systems. This work helps translate standard clinical adjustments into sequences of parameter tuning for each HCL system in order to provide a comprehensive guide for clinicians.

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