Abstract
Background and Aims
Currently there is no data among Asian Indians on the correlation between Time In Range(TIR) or Time In Target(TIT) and A1c. In this study, we have made an attempt to assess the correlation if any, from CGM obtained from our diabetes centres in Kerala, South India.
Methods
We divided the patient cohort of 200 into 4 categories; those with A1c values <7, 7 to 8, 8 to 9 and 9 to 10%. Subsequently, HbA1c values were paired against their corresponding TIT values from CGM data(Libre Pro) and reviewed to determine if any correlation existed between these metrics. Informed consent were obtained from study participants.
Results
HbA1c was paired with TIT% data and evaluated by Pearson’s Coefficient ratio. Among the subjects, those with HbA1c between 7-8% experienced stronger correlation ( R=0.4399, R2=0.1935) with a significant p value followed by patient cohort group 8-9%, with a moderate correlation while the other two cohorts gave a weak correlation value and had a p value of no clinical significance. In elderly subset of subjects (> 60 years), in accordance with International consensus for TIR, the target value > 50% was seen as HbA1c drops below 8%.
Conclusions
This study in Asian Indians shows a close alignment with TIR in accordance with the International Consensus on TIR for A1c between 7 and 9%. However in the other 2 cohorts the correlation is weaker implying the role of TIR as complementary and not as a replacement for A1c. In elderly, TIR becomes significant as A1c drops below 8%.
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