Light-emitting diode (LED) phototherapy regenerates pancreatic islets and alters carbohydrate metabolism Phototherapy has shown good results for cell proliferation and regeneration.We investigated the effects of LED (LED) irradiation in the pancreas injured to induction of experimental diabetes and we evaluated the morphological changes in pancreatic β cells.
For the experiment, we used twenty randomly selected Wistar rats in three groups: non-diabetic diabetic and diabetic control treated with LED Diabetes was induced by injection of streptozotocin. The irradiated group was treated with LED (λ = 805 nm; 40 mW, 22 s; 0.88 J), applied to the anatomical area of the pancreas for 5 consecutive days and evaluated after 30 days.
Islet and duct regeneration in the pancreas was observed after 30 days in the diabetic group treated with LED, and this regeneration was statistically significant when compared to the control group (p = 0.01). In the diabetic control group, hepatic glycogen content was lower when compared to diabetics with LED (p = 0.03). When performing the intraperitoneal insulin tolerance test, we observed differences between diabetic control and diabetic treatment groups (p = 0.03).
This study demonstrated that LED phototherapy allowed regeneration of pancreatic tissue, especially pancreatic islets and altered carbohydrate metabolism in an experimental model.