THE METABOLIC EFFECTS OF CONTINUOUS INTRA-PERITONEAL INSULIN INFUSION, A SYSTEMATIC REVIEW

Session Name
ARTIFICIAL PANCREAS
Session Type
E-POSTER VIEWING (EXHIBITION HOURS)
Date
20.02.2020, Thursday
Session Time
09:30 - 15:30
Channel
E-Poster Area
Lecture Time
09:37 - 09:38
Presenter
  • Ilze Dirnena-fusini, Norway
Authors
  • Ilze Dirnena-fusini, Norway
  • Marte Kierulf Åm, Norway
  • Anders L. Fougner, Norway
  • Sven M. Carlsen, Norway
  • Sverre C. Christiansen, Norway

Abstract

Background and Aims

Continuous intraperitoneal insulin administration (CIPII) has been used for decades but in a limited number of patients with type 1 diabetes mellitus (DM1). There exist many reports regarding the effects of CIPII, mostly compared to treatment with continuous subcutaneous insulin infusion (CSII) and/or multiple daily injections (MDI). However, a systematic review comparing metabolic effects of CIPII and CSII is missing.

Methods

In this systematic review we addressed all available studies which has been published before October 1, 2019, comparing metabolic effects between CIPII and CSII in DM1 patients.

No restrictions were made regarding age, gender or any other patient characteristics. Main comparators were long-term glucose control (at least 3 months on IPII) measured by HbA1c and short-term (one day for each intervention) for insulin absorption. For comparison for randomized studies, the Cochrane collaboration tools were used; for observational studies, the STROBE statement checklist was used; for case reports and case series IHE the Quality appraisal checklist was used.

Results

We give an overview of all available articles of CIPII and CSII, we summarize all observed metabolic effects, and the prevalence of technical complications where this was reported.

First main finding was that HbA1c levels tend to improve in both routes (CIPII and CSII) when DM1 patients are followed up throughout the period of time. Second main finding was that values of free insulin tend to be more rapid, increase higher with shorter period of elevation and shows lower level in plasma when used intraperitoneal route.

Conclusions

More information will be provided at the ATTD.

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