TESTING OF A NOVEL EXTENDED WEAR INFUSION SET WITH AND WITHOUT THE ADDITION OF HEPARIN

Session Name
INSULIN PUMPS
Session Type
E-POSTER VIEWING (EXHIBITION HOURS)
Date
20.02.2020, Thursday
Session Time
09:30 - 15:30
Channel
E-Poster Area
Lecture Time
09:35 - 09:36
Presenter
  • Bruce A. Buckingham, United States of America
Authors
  • Bruce A. Buckingham, United States of America
  • Tatiana Marcal, United States of America
  • Lance Hoffman, United States of America
  • Gina Zhang, United States of America
  • Sarnath Chattaraj, United States of America

Abstract

Background and Aims

Background and Aims: Insulin infusion sets are one of the weak links in pump therapy and closed-loop systems. We conducted a randomized blinded study testing a novel infusion set which with and without heparin, hypothesizing that a small amount of heparin infused over multiple days would decrease thrombosis and inflammation around catheters.

Methods

Methods: The catheter hub with cannula was the MiniMed™ Quick-set ™ with a new tubing connector and hub. The connector was modified to contain an inert non-heparin (P) or heparin (80 units) (H) added to the P. Visibly the sets were identical and the study was double blinded. Four infusion sets (two P and two H) were worn by each subject for 7 days or until failure.

Results

Results: 20 subjects were studied (mean age 29.5±8 years). Median (IQR) duration of wear for 40 sets with H was 6.97 (6.5, 7) days and for 40 sets with P was 6.98 (6, 7) days. There were 9 sets in each group that failed before the 6th day. The mean total daily insulin dose and mean of sensor readings between 2 AM and 6 AM did not differ between the two groups and did not change with day of wear.

survival h andp and quickset.jpg

Conclusions

Conclusions: There was no difference between the two groups with the modified caps containing either a non-heparin (placebo), or the placebo combined with heparin in overall duration of wear. Both the non-Heparin and Heparin Extended Wear infusion sets had a longer length of wear compared to historical studies using a Quick-Set.

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