To do comparative analysis of the level of asymmetrical dimetilarginin in two groups of the patients with controlled and uncontrolled diabetes mellitus.
94 patients were divided into 2 groups. Group I – 53 patients with uncontrolled diabetes mellitus. Group II – 41 patients with controlled diabetes mellitus. Was done clinical, laboratory and instrumental methods of examination including the levels of asymmetrical dimetilarginin, creatinine in the blood and calculated glomerular filtration rate.
During the comparative analysis concentration of asymmetrical dimetilarginin in patients of group I was higher, and was found significant positive correlation between the levels of asymmetrical dimetilarginin and creatinine. (P<0,05). Increase of the level of asymmetrical dimetilarginin in blood was in correlation with decrease of glomerular filtration rate.
In both groups was found increase of the level of asymmetrical dimetilarginin, but the level of asymmetrical dimetilarginin was higher for the patients of group I. According on our findings during the uncontrolled diabetes mellitus manifestation of endothelial dysfunction was significantly visible. Positive correlation between the levels of asymmetrical dimetilarginin and glomerular filtration rate in uncontrolled diabetic patients shows possibility to use this substance as a marker of damages of target organs.