ENDOTHELIAL DYSFUNCTION IN PATIENTS WITH CONTROLLED AND UNCONTROLLED DIABETES MELLITUS

Session Name
E-POSTER DISCUSSION 09
Session Type
E-POSTER DISCUSSION
Date
21.02.2020, Friday
Session Time
10:05 - 10:25
Channel
Station 3 (E-Poster Area)
Lecture Time
10:20 - 10:25
Presenter
  • Khatuna Tchaava, Georgia
Authors
  • Khatuna Tchaava, Georgia
  • Nino Gegeshidze, Georgia
  • Mikheil Shavdia, Georgia
  • Nana Ninashvili, Georgia

Abstract

Background and Aims

To do comparative analysis of the level of asymmetrical dimetilarginin in two groups of the patients with controlled and uncontrolled diabetes mellitus.

Methods

94 patients were divided into 2 groups. Group I – 53 patients with uncontrolled diabetes mellitus. Group II – 41 patients with controlled diabetes mellitus. Was done clinical, laboratory and instrumental methods of examination including the levels of asymmetrical dimetilarginin, creatinine in the blood and calculated glomerular filtration rate.

Results

During the comparative analysis concentration of asymmetrical dimetilarginin in patients of group I was higher, and was found significant positive correlation between the levels of asymmetrical dimetilarginin and creatinine. (P<0,05). Increase of the level of asymmetrical dimetilarginin in blood was in correlation with decrease of glomerular filtration rate.

Conclusions

In both groups was found increase of the level of asymmetrical dimetilarginin, but the level of asymmetrical dimetilarginin was higher for the patients of group I. According on our findings during the uncontrolled diabetes mellitus manifestation of endothelial dysfunction was significantly visible. Positive correlation between the levels of asymmetrical dimetilarginin and glomerular filtration rate in uncontrolled diabetic patients shows possibility to use this substance as a marker of damages of target organs.

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