INSULINE RESISTANCE – PATOGENESIS, PREVENTION AND TREATMENT

Session Name
GLUCOSE SENSORS
Session Type
E-POSTER VIEWING (EXHIBITION HOURS)
Date
20.02.2020, Thursday
Session Time
09:30 - 15:30
Channel
E-Poster Area
Lecture Time
09:30 - 09:30
Presenter
  • Emil K. Mukhamejanov, Kazakhstan
Authors
  • Emil K. Mukhamejanov, Kazakhstan

Abstract

Background and Aims

The mechanism of development of insulin resistance (IR) is not clear. This makes it difficult to develop adequate ways to prevent and treat type 2 diabetes mellitus (2D).

Methods

The rats with aloxane diabetes.

Results

There is no free glucose in the muscle tissue, upon admission it is immediately phosphorylated to glucose-6-phosphate (G-6-F), which prevents its return. With a decrease in the rate of G-6-F conversion, hexokinase is inhibited and the intake of glucose into the muscles decreases. This regulatory process can be considered as the first mechanism of development of insulin resistance. The next regulatory step is the process of assimilation of pyruvic acid or the so-called pyruvate block, since a decrease in anaerobic or aerobic conversion of pyruvate promotes inhibition of glycolysis and the development of insulin resistance. The next step in the regulation of glucose conversion is ATP or the level of utilization of the energy of its oxidation. The most volatile process in the muscle cell is protein synthesis, so the amount of glucose utilization will directly correlate with the rate of protein synthesis. With a decrease in protein synthesis with a substrate deficit or inhibition of the protein of the synthesizing apparatus, the utilization of ATP decreases and the ATP / PDP coefficient increases, which contributes to the inhibition of hexokinase and the development of insulin resistance.

Conclusions

Such mechanism of development of insulin resistance will allow to develop effective ways of developing the principles of prevention and treatment of patients with 2D.

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