LOWER LIMB ARTERIAL INTERVENTION OR AUTOLOGOUS PLATELET-RICH GEL TREATMENT OF DIABETIC LOWER EXTREMITY ARTERIAL DISEASE WITH FOOT ULCER

Session Name
ADVANCED MEDICAL TECHNOLOGIES TO BE USED IN HOSPITALS
Session Type
E-POSTER VIEWING (EXHIBITION HOURS)
Date
20.02.2020, Thursday
Session Time
09:30 - 15:30
Channel
E-Poster Area
Lecture Time
09:42 - 09:43
Presenter
  • Wu Qinan, China
Authors
  • Wu Qinan, China

Abstract

Background and Aims

To investigate whether the Lower limb vascular intervention or Autologous platelet-rich gel (APR) treatment would benefit patients with diabetic lower extremity arterial disease (LEAD) with foot ulcer.

Methods

A total 82 diabetic LEAD with foot ulcer patients were recruited and divided into 3 groups: group A (30 patients received basal treatment), group B (21 patients received basal and autologous platelet-rich gel treatment), group C (31 patients received basal and Lower limb vascular intervention treatment), all patients had a routine follow-up visit for 6 months. The baseline characters and parameters were detected. After treatment, changes from baseline of all parameters were recorded. The differences among each groups and the relationship among each parameters were conducted.

Results

There were no difference in ABI and major amputation between group A and B (P>0.05), compared with group A and B, the ABI and major amputation rate of the C group were improved (P<0.05); There were no significant difference in Tcpo2, heal rate and minor amputation between A and C group (P>0.05), and compared with group A and C, the Tcpo2, heal rate and minor amputation of B group were improved (P<0.05). The logistic regression analysis indicated that the major amputation was mainly associated with ABI, and the minor amputation was mainly associated with Tcpo2. The lower limb vascular intervention can improve the ABI and reduce the major amputation, and the APR improves the Tcpo2 and reduces the minor amputation.

Conclusions

In diabetic LEAD with foot ulcer, major amputation was mainly associated with ABI, while minor amputation was mainly associated with Tcpo2. Interventional surgery mainly improves the ABI and reduces the incidence of major amputation with the improvement of macro-vascular, and the APR mainly improves the local Tcpo2, and reduces the incidence of minor amputations with the improvement of microcirculation.

Hide