e-Poster Display Session (ID 87) Poster Display

131P - Prognostic value of tumour regression grading (TRG) in patients treated with neoadjuvant chemotherapy plus surgery for gastric cancer (ID 500)

Presentation Number
Lecture Time
09:00 - 09:00
  • Jian-Wei Xie (Fuzhou, China)
On-Demand e-Poster Display, Virtual Meeting, Virtual Meeting, Singapore
09:00 - 20:00



The factors associated with a better tumor response rate and an optimal neoadjuvant chemotherapy regimen are uncertain. We aimed to validate the prognostic value of tumor regression grading (TRG) and explore the associated factors of TRG for advanced gastric cancer (AGC) with neoadjuvant chemotherapy (NACT) plus surgery.


Three hundred forty-four AGC patients treated with NACT followed by gastrectomy at the Mayo Clinic, USA and the Fujian Medical University Union Hospital, China between January 2000 and December 2016 were enrolled in this study. Cox regression was used to identify covariates associated with overall survival (OS) and recurrence-free survival (RFS). Logistic regression was used to reveal factors predicting the tumor regression grading.


For patients with TRG 0-1, the 3- and 5-year OS rates were 85.2% and 74.5%, respectively, when compared to 56.1% and 44.1% in patients with TRG 2 and 28.2% and 23.0% in patients with TRG 3, respectively(p=0.000). TRGs were independent risk factors for OS. Similar findings were observed in RFS. The oxaliplatin-based regimen was superior to the non-oxaliplatin-based regimen for the OS (38.4m vs 19.5m, respectively; p=0.01). Subgroup analyses by histological subtype indicated that the oxaliplatin-based regimen improved the OS in non-signet ring cell carcinoma compared to the non-oxaliplatin-based regimen (53.7m vs 19.5m, respectively; p=0.011). However, Similar findings were not observed in RFS.


TRG was an independent factor of AGC treated with neoadjuvant chemotherapy plus surgery. Oxaliplatin-based neoadjuvant chemotherapy regimens improve tumor response and may have an overall survival benefit for patients with non-signet ring cell carcinoma.

Legal entity responsible for the study

The authors.


Scientific and Technological Innovation Joint Capital Projects of Fujian Province.


All authors have declared no conflicts of interest.