e-Poster Display Session (ID 87) Poster Display

YO7 - Locally Advanced Rectal Cancer- A Case Report (ID 340)

Presentation Number
Lecture Time
09:00 - 09:00
  • Uthaman Jithin (Chongqing, China)
On-Demand e-Poster Display, Virtual Meeting, Virtual Meeting, Singapore
09:00 - 20:00


Case summary

-Female 61 y.o

-Rectal prolapse and hematochezia for 6 months

-BSF Scale- type 6 for half a year

-Up on DRE a mass of identified -6 cm from the anal edge

-April 2018- Colonoscopy identified a cauliflower-like mass 6 cm from the Anal dentate line.

- Pathological diagnosis: poorly differentiated adenocarcinoma of the rectum.

►Immunohistochemistry: CK (+), P53 (+), Ki-67 (80%), CEA (-), CD20 (-)

►Pelvic Contrast-Enhanced CT- April 2018

-Thickening of the intestinal wall in the lower rectum, narrowing of the intestine and no obvious enlarged lymph nodes noted.

►Abdomen CT- Normal -CEA-17.31ng/ml,ECOG score 0

-liver and kidney function- Normal, normal ECG

►Clinical diagnosis

-Poorly differentiated adenocarcinoma in the lower rectum. Clinical stage: T4N0M0, stage IIb

►Multidisciplinary team-MDT

-Department of Radiology- The lower intestinal wall is thickened in the lower rectum, and the intestinal lumen is narrow.

-Gastrointestinal Surgery- Resectable - radical resection? Anal sphincter preservation?

-Radiotherapy-Preoperative radiotherapy

-Department of Oncology-Neoadjuvant chemoradiotherapy + surgical treatment

►First-line Treatment

-Radiotherapy- 50.4Gy/28 fractions/5.6 weeks

-Chemotherapy- (1-14 days) and(22-35 days)Tegafur 65 mg/m2

Review -June 2018 Colonoscopy

-Diagnosis: rectal mucosal chronic inflammation.

-Pathology CEA: 2.71ng/ml, liver and kidney function normal, ECOG score 0.

Pelvic CT-June 2018: thickening of the rectal wall, marginal irregularity- Evaluation of efficacy: cPR

►Surgery-July 2018:Laparoscopic radical resection of rectal cancer, sigmoid colon-rectal anastomosis

Review-6 months post-surgery: anterior sputum effusion. Carcinoembryonic antigen: 0.68 ng/ml-Efficacy: cCR

1.The best option for neoadjuvant therapy?

A.Combination chemotherapy Tegafur + oxaliplatin



2.If the patient reaches cCR after neoadjuvant therapy?

A. Watch and wait

B. Postoperative radiotherapy