It is generally well known that the use of magnetic fields has an undoubtedly long-range potential when aided with high substance permeability, although their essential forces must be of low energies. That’s why numerous techniques have been developed to investigate magnetic nanoparticles for biomedical engineering applications to drug-delivery systems (DDSs). On the other hand, judging from the best of our knowledge, there are almost no reported studies of the application of radical pair mechanisms (RPMs) to drug-release controlling under exposure to magnetic fields.
The triplet yield Φ
When the magnetic field strength was set up in the range of 0.1–0.2 T, competition between MFEs and the FM-related escape-radical release was observed depending on the field strength. In contrast, MFEs with a field of 40 mT were not extensive under our experimental conditions. Concerning three kinds of liposomes prepared in this study, the field effects obtained using a homogenous field of 0.2 T were more extensive on the order of 67%–75%, than those obtained at a geomagnetic field.
In this study, we considered applying the RPM to DDS methodologies for the best possible balance between clinical performance and low invasivity. Our liposomal drug-release technology with magnetic controls must be one of the most adaptable DDS.
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Japan Society for the Promotion of Science (JSPS)
All authors have declared no conflicts of interest.