An ILO report from this year found that there are over 476 million Indigenous people in the world. They make up less than 5% of the population, represent 15% of the world’s poorest people and yet manage more than one-quarter of the world’s land surface. Global indicators and targets for Indigenous Peoples often exclude them. This Symposium will examine the global targets for HIV such as Getting to Zero by 2030 also exploring the Sustainable Development Goals (SDGs) and how Indigenous Peoples play an important role in achieving them. Although all of the 17 SDGs are relevant for Indigenous Peoples, they are mentioned specifically in Goals 2 and 4. Ensuring that SDG implementation takes place in conformity with the United Nations Declaration on the Rights of Indigenous Peoples is essential. It is our collective responsibility to support Indigenous Peoples and, ultimately, the well-being of our planet.