Antiretroviral therapy (ART) has improved dramatically over the past decade. This progress has yielded more treatment choices for clinicians and patients but also adds greater complexity to the already diverse field of HIV treatment. Clinicians must keep apprised of new data on treatment strategies, including drug simplification and long-acting injectables, selection of appropriate individualized therapy, and effective management of treatment side effects. In this interactive, case-based program, expert faculty will provide guidance on how to incorporate new treatment strategies into clinical practice. They will also discuss various aspects of HIV management, including the selection of an initial antiretroviral regimen for a patient with advanced disease; treatment modification in women; and treatment simplification.