Stigma and discrimination are significant challenges in reaching and maintaining treatment success and self-management for adolescents and youth living with HIV (AYLHIV). Stigma-related challenges infiltrate home, school, clinics, friendships and relationships; finding a way to discuss and combat stigma is a vital step in the HIV response. The Committee of African Youth Advisors (CAYA), the internal youth engagement mechanism of the Elizabeth Glaser Pediatric AIDS Foundation (EGPAF), developed a set of cartoons specifically to address stigma. CAYA members (AYLHIV under 30 years old) developed four scene cartoons on various case studies of stigma and discrimination within their own contexts and countries. These, accompanied by discussion questions, allow AYLHIV in support groups to have guided, informative, and productive conversations about scenarios made by fellow youth living with HIV. Cartoons are used in 10 countries and have been translated into French.