I am a neurology trainee, based in London. I am currently undertaking my PhD, investigating the neuropathology of posterior cortical atrophy (PCA), at the Queen Square Brain Bank, University College London. PCA is a variant of Alzheimer’s disease (AD) which presents with visual and spatial problems rather than the memory problems seen in typical Alzheimer’s disease (TAD). The pathological proteins in PCA and TAD are the same: Aβ plaques and tau neurofibrillary tangles (NFTs). The question therefore is how the same underlying pathology causes such dramatically different clinical presentations and whether these two variants of AD start in different “selectively vulnerable” parts of the brain, or indeed have differing patterns of cortical spread and severity. There is an accumulating wealth of evidence towards distinct subtypes of AD based mainly on neuropathological and imaging studies although the potential biological mechanisms driving this heterogeneity remain unanswered. My aim is to carry out a comprehensive neuropathological characterisation of PCA cases including regional Aβ and NFT quantification, investigation of neuroinflammatory markers and proteomic studies.