G. d'Annunzio University of Chieti-Pescara
Department of Medicine and Aging Sciences
My main research interests are focused upon Lewy body disease. My studies (in particular neurohysiological studies based on EEG evaluation of Dementia with Lewy bodies specific features) have contributed to the drawing up of the last version of the globally used Consensus criteria for the clinical and pathological diagnosis and management of dementia with Lewy bodies (DLB) and related disorders. The quantitative EEG method developed by me allowed to identify a supportive biomarker for the diagnosis . This was the first time that EEG was defined as a biomarker for a neurodegenerative dementia. I published extensively in the field of Lewy body disease and neurodegenerative conditions. These studies range from clinical to neurophysiological to neuroimaging methods to assess phenomenology and pathophysiology of Lewy Body Disease. During my education I also learned and applied neurophysiological methods to study the mechanisms underlying neurodegeneration on a neuronal and tissue (slices from animal models of neurodegeneration) basis. This allowed me to reach a more open view of neurodegenerative diseases, ranging from cell to system. I am member of the Steering Committee of the European DLB study group; Program Chair of Lewy body Dementia (LBD)-Professional Interest Areas (PIA) (ISTAART-AAIC); Chair of the prodromal Lewy Body Dementia work group of the LBD-PIA; National Secretary of the Italian Society of Neurology-Dementia; National coordinator of the Italian DLB study group under the aegis of the Italian Society of Neurology-Dementia.

Moderator of 1 Session

Session Type
SYMPOSIUM
Date
Sat, 19.03.2022
Session Time
05:15 PM - 07:45 PM
Room
ONSITE: 131-132

Presenter of 1 Presentation

CORTICAL NETWORK MODULARITY CHANGES ALONG THE COURSE OF FRONTOTEMPORAL AND ALZHEIMER’S DEMENTING DISEASES

Session Type
SYMPOSIUM
Date
Sat, 19.03.2022
Session Time
05:15 PM - 07:45 PM
Room
ONSITE: 131-132
Lecture Time
05:45 PM - 06:00 PM

Abstract

Aims

Cortical network modularity underpins cognitive functions, so we hypothesized its progressive derangement along the course of frontotemporal (FTD) and Alzheimer’s (AD) diseases.

Methods

EEG was recorded in 18 FTD, 18 AD, and 20 healthy controls (HC). In the FTD and AD patients, the EEG recordings were performed at the prodromal stage of dementia, at the onset of dementia, and three years after the onset of dementia. HC underwent three EEG recordings at 2-3-year time interval. Information flows underlying EEG activity recorded at electrode pairs were estimated by means of Mutual Information (MI) analysis. The functional organization of the cortical network was modelled by means of the Graph theory analysis on MI adjacency matrices.

Results

Graph theory analysis showed that the main hub of HC (Parietal area) was lost in FTD patients at onset of dementia, substituted by provincial hubs in frontal leads. No changes in global network organization were found in AD.

Conclusions

Results showed that the parietal “main hub” of HC and AD patients was lost in the FTD patients at the dementia onset, substituted by frontal “provincial hubs” and local “small worlds”. No change in global network organization was found in AD patients during the disease progression.
Despite a progressive cognitive impairment during the FTD and AD progression, only the FTD patients showed a derangement in the cortical network modularity, possibly due to dysfunctions in frontal functional connectivity.

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