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RELATIONSHIP BETWEEN CSF ABETA42/40 AND [18F]FLUTEMETAMOL PET-DERIVED CENTILOID UNITS IN SUBJECTIVE COGNITIVE DECLINE AND MILD COGNITIVE IMPAIRMENT
Abstract
Aims
To apply the Centiloid PET quantitation Atlas to quantify [18F]flutemetamol brain images and investigate the relationship between Centiloid and CSF Aβ42/40 in patients with Subjective Cognitive Decline (SCD) or Mild Cognitive Impairment (MCI).
Methods
The Centiloid atlas was applied to a cohort of 387 [18F]flutemetamol images obtained from subjects from the Swedish BioFINDER I study, following the methods described by Klunk et.al. (Alzheimer’s & Dementia, 2015). Subjects, comprising Controls (n=128), SCD (n=114) and MCI (n=145) were included for analysis based on the availability of CSF Aβ42/40 information. CSF Aβ were determined using the ADx analysis platform.
Results
Mean (±SD) CSF Aβ42/40 ratios were 0.146 (±0.032) for Subjects in CL bands ranging from -20(±5) CL to 20(±5) CL. Subjects in the 30(±5) CL band were significantly higher (p=0.0155) in average CSF Aβ42/40 ratios (0.138 ± 0.042) than Subjects in the 40(±5) CL band (0.100 ± 0.036). The average CSF Aβ42/40 ratios value for all Subjects ranging from 50(±5) Cl to >135 CL was 0.073 (±0.019).
Conclusions
The comparison of [18F]flutemetamol image quantitation and CSF Aβ42/40 indicates that CSF Aβ42/40 shows amyloid positivity at approximately 30 CL units. Recent comparisons between visual rating and Centiloids from PET imaging indicate visual positivity beginning at approximately 20 CL units – indicating that PET imaging to be competitive with CSF Aβ42/40 measures for the detection of early amyloid.