Yakeel T. Quiroz, United States of America
Harvard Medical School and Massachusetts General Hospital (MGH) Departments of Psychiatry and NeurologyAuthor Of 1 Presentation
AGE-RELATED TRAJECTORY OF TAU PATHOLOGY IN PRECLINICAL AUTOSOMAL DOMINANT ALZHEIMER'S DISEASE
Abstract
Abstract Body
Aims
Examine baseline and longitudinal brain pathology (amyloid and tau) and memory decline in cognitively-unimpaired carriers of autosomal dominant Alzheimer's disease.
Methods
Members of the Colombian kindred with the PSEN1 E280A ADAD were enrolled in our ongoing study (40 nondemented carriers and 40 age-matched non-carriers; age 36 +/- 6 years old). Participants underwent a comprehensive neuropsychological evaluation, and Positron Emission Tomography (PET) scanning to measure cortical amyloid and regional tau burden (i.e., inferior temporal tau and entorhinal tau). Mann-Whitney tests and Spearman correlations were conducted to examine group differences and relationships among cognitive performance and AD pathology.
Results
Carriers performed significantly worse on MMSE (p=.001) and CERAD Word List Learning (p=.003), and had greater cortical amyloid (p<.001) and entorhinal tau burden (p=.025), compared to non-carriers. Memory scores negatively correlated with markers of AD pathology (p<.001).
Conclusions
Our results suggest that verbal memory decline relates to markers of AD pathology in cognitively-unimpaired individuals with PSEN1 E280A ADAD. Future research is needed to examine whether memory measures such as the CERAD Word List Learning may be useful in detecting subtle cognitive changes in those at risk for AD, prior to clinical onset.
Presenter of 2 Presentations
LIVE DISCUSSION
AGE-RELATED TRAJECTORY OF TAU PATHOLOGY IN PRECLINICAL AUTOSOMAL DOMINANT ALZHEIMER'S DISEASE
Abstract
Abstract Body
Aims
Examine baseline and longitudinal brain pathology (amyloid and tau) and memory decline in cognitively-unimpaired carriers of autosomal dominant Alzheimer's disease.
Methods
Members of the Colombian kindred with the PSEN1 E280A ADAD were enrolled in our ongoing study (40 nondemented carriers and 40 age-matched non-carriers; age 36 +/- 6 years old). Participants underwent a comprehensive neuropsychological evaluation, and Positron Emission Tomography (PET) scanning to measure cortical amyloid and regional tau burden (i.e., inferior temporal tau and entorhinal tau). Mann-Whitney tests and Spearman correlations were conducted to examine group differences and relationships among cognitive performance and AD pathology.
Results
Carriers performed significantly worse on MMSE (p=.001) and CERAD Word List Learning (p=.003), and had greater cortical amyloid (p<.001) and entorhinal tau burden (p=.025), compared to non-carriers. Memory scores negatively correlated with markers of AD pathology (p<.001).
Conclusions
Our results suggest that verbal memory decline relates to markers of AD pathology in cognitively-unimpaired individuals with PSEN1 E280A ADAD. Future research is needed to examine whether memory measures such as the CERAD Word List Learning may be useful in detecting subtle cognitive changes in those at risk for AD, prior to clinical onset.