Karol Enrique Uscamaita Amaut, Spain
AdSalutem Institute Sleep Medicine NeurologyAuthor Of 1 Presentation
CAN SLEEP/WAKE CYCLE PATTERNS CAUSE ND?
Abstract
Aims
Sleep/wake cycle alterations are common in Parkinson’s disease (PD) and Alzheimer’s disease (AD). Traditionally, they have been described as early manifestations in PD and AD. However, observational studies suggest that they could also be causal risk factors for these neurodegenerative diseases. Our aim was to determine whether there is a causal relationship between sleep/wake cycle patterns and age at onset (AAO) of PD and AD using two-sample Mendelian Randomization (MR).
Methods
We selected 12 sleep traits (exposure) with available Genome-Wide Association Study (GWAS) data to evaluate their causal relationship with the risk of PD and AD (considered the outcome variables) through Inverse-Variance Weighted regression. We selected the genome-wide significant polymorphisms from the exposure and extracted them in the largest GWAS with available summary-statistics selected as outcomes: PD AAO (N=17,996) and AD (N=21,235). Sensitivity analyses were performed to confirm the results.
Results
MR results suggested a causal effect of morning chronotype, based on subjective and objective measures, on later PD AAO (95%CI: 1.20-2.43, p=8.47x10-09 and 95% CI:-7.28 to -4.44, p=5.87x10-16, respectively). Sleep efficiency was causally related with a lower risk of AD (95% CI:-20.408 to -0.66, p=0.04). These results were confirmed after sensitivity analyses.
Conclusions
This study suggest a potential causal effect of morning chronotype in PD AAO and sleep efficiency with a lower risk of AD. Given that sleep/wake patterns may be modifiable risk factors, they could be investigated further in order to potentially reduce the PD and AD risk.