Luigi Albano, Italy
IRCCS San Raffaele Scientific Institute and Vita-Salute San Raffaele University Division of NeuroscienceAuthor Of 2 Presentations
FUNCTIONAL CONNECTIVITY AS AN EARLY MARKER OF INDICATION FOR DEEP BRAIN STIMULATION TREATMENT IN PARKINSON’S DISEASE
Abstract
Aims
The aim of this study was to identify early neuroimaging biomarkers of the need for deep brain stimulation (DBS) use in patients with Parkinson’s Disease (PD).
Methods
PD patients performed clinical-cognitive evaluations and resting-state functional MRI (RS-fMRI) at baseline and every year for 4 years. Patients were divided into two groups: 19 patients eligible for DBS (PD-DBS) over 48 months and 41 patients who did not meet the criteria to undergo DBS surgery (PD-noDBS). 60 age- and sex-matched controls performed baseline assessments. Graph analysis/connectomics assessed global and local topological network properties and regional functional connectivity (FC) at baseline and changes over-time.
Results
Lobar network analysis showed a significant higher mean nodal strength, local efficiency and clustering coefficient of the occipital areas in PD-DBS relative to both controls and PD-noDBS at baseline. These results were then confirmed by regional analysis. A significant increased FC between frontal and basal ganglia networks was found in PD-noDBS compared to both controls and PD-DBS patient at baseline. Referring to longitudinal analysis, PD-DBS patients showed a progressive decreased FC within occipital and between occipital and parietal networks compared to PD-noDBS (stable over time). Progressive decreased FC between frontal and basal ganglia networks occurred in PD-noDBS relative to PD-DBS (stable over time). Functional alterations within occipital network were positively related to tremor only in PD-DBS at baseline and over time.
Conclusions
RS-fMRI analysis might represent an early biomarker that helps clinicians to establish the correct indication for DBS in PD patients. Funding:Ministry of Education and Science Republic of Serbia (Grant#175090).
LIVE DISCUSSION
Presenter of 2 Presentations
FUNCTIONAL CONNECTIVITY AS AN EARLY MARKER OF INDICATION FOR DEEP BRAIN STIMULATION TREATMENT IN PARKINSON’S DISEASE
Abstract
Aims
The aim of this study was to identify early neuroimaging biomarkers of the need for deep brain stimulation (DBS) use in patients with Parkinson’s Disease (PD).
Methods
PD patients performed clinical-cognitive evaluations and resting-state functional MRI (RS-fMRI) at baseline and every year for 4 years. Patients were divided into two groups: 19 patients eligible for DBS (PD-DBS) over 48 months and 41 patients who did not meet the criteria to undergo DBS surgery (PD-noDBS). 60 age- and sex-matched controls performed baseline assessments. Graph analysis/connectomics assessed global and local topological network properties and regional functional connectivity (FC) at baseline and changes over-time.
Results
Lobar network analysis showed a significant higher mean nodal strength, local efficiency and clustering coefficient of the occipital areas in PD-DBS relative to both controls and PD-noDBS at baseline. These results were then confirmed by regional analysis. A significant increased FC between frontal and basal ganglia networks was found in PD-noDBS compared to both controls and PD-DBS patient at baseline. Referring to longitudinal analysis, PD-DBS patients showed a progressive decreased FC within occipital and between occipital and parietal networks compared to PD-noDBS (stable over time). Progressive decreased FC between frontal and basal ganglia networks occurred in PD-noDBS relative to PD-DBS (stable over time). Functional alterations within occipital network were positively related to tremor only in PD-DBS at baseline and over time.
Conclusions
RS-fMRI analysis might represent an early biomarker that helps clinicians to establish the correct indication for DBS in PD patients. Funding:Ministry of Education and Science Republic of Serbia (Grant#175090).
LIVE DISCUSSION